COVID-19 diagnosis - a review of current methods

Yüce, Meral and Filiztekin, Elif and Özkaya, Korin Gasia (2021) COVID-19 diagnosis - a review of current methods. Biosensors and Bioelectronics, 172 . ISSN 0956-5663 (Print) 1873-4235 (Online)

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A fast and accurate self-testing tool for COVID-19 diagnosis has become a prerequisite to comprehend the exact number of cases worldwide and to take medical and governmental actions accordingly. SARS-CoV-2 (formerly, 2019-nCoV) infection was first reported in Wuhan (China) in December 2019, and then it has rapidly spread around the world, causing ~14 million active cases with ~582,000 deaths as of July 2020. The diagnosis tools available so far have been based on a) viral gene detection, b) human antibody detection, and c) viral antigen detection, among which the viral gene detection by RT-PCR has been found as the most reliable technique. In this report, the current SARS-CoV-2 detection kits, exclusively the ones that were issued an “Emergency Use Authorization” from the U.S. Food and Drug Administration, were discussed. The key structural components of the virus were presented to provide the audience with an understanding of the scientific principles behind the testing tools. The methods that are still in the early research state were also reviewed in a subsection based on the reports available so far.
Item Type: Article
Uncontrolled Keywords: COVID-19; Lateral flow assay; Loop-mediated isothermal amplification; Point of care devices; RT-PCR; SARS-CoV-2 detection; SARS-CoV-2 diagnosis
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Meral Yüce
Date Deposited: 16 Aug 2022 16:07
Last Modified: 16 Aug 2022 16:07

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