Role of microRNA/epithelial‐to‐mesenchymal transition axis in the metastasis of bladder cancer

Ashrafizadeh, Milad and Hushmandi, Kiavash and Hashemi, Mehrdad and Akbari, Mohammad Esmaeil and Kubatka, Peter and Raei, Mehdi and Koklesova, Lenka and Shahinozzaman, Md and Mohammadinejad, Reza and Najafi, Masoud and Sethi, Gautam and Kumar, Alan Prem and Zarrabi, Ali (2020) Role of microRNA/epithelial‐to‐mesenchymal transition axis in the metastasis of bladder cancer. Biomolecules, 10 (8). ISSN 2218-273X

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Bladder cancer (BC) is the 11th most common diagnosed cancer, and a number of factors including environmental and genetic ones participate in BC development. Metastasis of BC cells into neighboring and distant tissues significantly reduces overall survival of patients with this lifethreatening disorder. Recently, studies have focused on revealing molecular pathways involved in metastasis of BC cells, and in this review, we focus on microRNAs (miRNAs) and their regulatory effect on epithelial‐to‐mesenchymal transition (EMT) mechanisms that can regulate metastasis. EMT is a vital process for migration of BC cells, and inhibition of this mechanism restricts invasion of BC cells. MiRNAs are endogenous non‐coding RNAs with 19—24 nucleotides capable of regulating different cellular events, and EMT is one of them. In BC cells, miRNAs are able to both induce and/or inhibit EMT. For regulation of EMT, miRNAs affect different molecular pathways such as transforming growth factor‐beta (TGF‐β), Snail, Slug, ZEB1/2, CD44, NSBP1, which are, discussed in detail this review. Besides, miRNA/EMT axis can also be regulated by upstream mediators such as lncRNAs, circRNAs and targeted by diverse anti‐tumor agents. These topics are also discussed here to reveal diverse molecular pathways involved in migration of BC cells and strategies to target them to develop effective therapeutics.
Item Type: Article
Uncontrolled Keywords: Bladder cancer; Cancer therapy; Epithelial‐to‐mesenchymal transition (EMT); Metastasis; microRNA (miRNA)
Divisions: Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 10 Aug 2022 15:09
Last Modified: 10 Aug 2022 15:09

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