Core-shell PVA/gelatin nanofibrous scaffolds using co-solvent, aqueous electrospinning: toward a green approach

Şengör, Mustafa and Özgün, Alp and Çorapcıoğlu, Gülcan and İpekoğlu, Mehmet and Garipcan, Bora and Ersoy, Nuri and Altıntaş, Sabri (2018) Core-shell PVA/gelatin nanofibrous scaffolds using co-solvent, aqueous electrospinning: toward a green approach. Journal of Applied Polymer Science, 135 (32). ISSN 0021-8995 (Print) 1097-4628 (Online)

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Abstract

Electrospinning (ES) of gelatin often requires cytotoxic organic solvents or acidic environments, which deteriorate cell rec-ognition sites. In this study, aqueous, non-toxic, co-solvent ES was performed to obtain core–shell poly(vinyl alcohol) (PVA)/gelatinnanofiber scaffolds. Effects of the core/shell feed rate ratio (FRR) were investigated on a morphological and mechanical basis. PVA:ge-latin ratio of 1:4 was the limiting ratio for specific voltage and electrode distance parameters to obtain uniform fibers. Core–shellbead-free structures were obtained at 8% PVA and gelatin aqueous solutions. A mean diameter of 280 nm was obtained for 1:1 FRRat 15 kV and 15 cm of electrode distance. Crosslinking resulted in slight improvement in tensile strengths and severe decrease in duc-tility. Fourier transform infrared spectra revealed retention and improvement of stable secondary structures of gelatin after ES. Thescaffolds almost degraded more than 60% in 14 days. Based on the results, present scaffolds hold great promise as suitable candidatesfor biomedical applications.
Item Type: Article
Uncontrolled Keywords: biodegradable; biomaterials; biomedical applications; electrospinning; fibers
Divisions: Sabancı University Nanotechnology Research and Application Center
Faculty of Engineering and Natural Sciences
Depositing User: Gülcan Çorapcıoğlu
Date Deposited: 17 Aug 2018 09:59
Last Modified: 26 Apr 2022 09:58
URI: https://research.sabanciuniv.edu/id/eprint/35774

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