Screening of new antileukemic agents from essential oils of algae extracts and computational modeling of their interactions with intracellular signaling nodes

Warning The system is temporarily closed to updates for reporting purpose.

Atasever-Arslan, Belkıs and Yılancıoğlu, Kaan and Kalkan, Zeynep and Timuçin, Ahmet Can and Gür, Hazal and Işık, Fatma Büşra and Deniz, Emre and Erman, Batu and Çetiner, Selim (2016) Screening of new antileukemic agents from essential oils of algae extracts and computational modeling of their interactions with intracellular signaling nodes. European Journal of Pharmaceutical Sciences, 83 . pp. 120-131. ISSN 0928-0987 (Print) 1879-0720 (Online)

[thumbnail of Screening_of_New_Antileukemic_Agents_from_Essential_Oils_of_Algae_Extracts_and_Computational_Modelling_of_Their_Interactions_with_Intracellular_Signalling_Nodes.pdf] PDF
Screening_of_New_Antileukemic_Agents_from_Essential_Oils_of_Algae_Extracts_and_Computational_Modelling_of_Their_Interactions_with_Intracellular_Signalling_Nodes.pdf
Restricted to Registered users only

Download (1MB) | Request a copy

Abstract

Microalgae are very rich in bioactive compounds, minerals, polysaccharides, poly-unsaturated fatty acids and vitamins, and these rich constituents make microalgae an important resource for the discovery of new bioactive compounds with applications in biotechnology. In this study, we studied the antileukemic activity of several chosen microalgae species at the molecular level and assessed their potential for drug development. Here we identified Stichococcus bacillaris, Phaeodactylum tricornutum, Microcystis aeruginosa and Nannochloropsis oculata microalgae extracts with possible antileukemic agent potentials. Specifically we studied the effects of these extracts on intracellular signal nodes and apoptotic pathways. We characterized the composition of essential oils of these fifteen different algae extracts using gas chromatography–mass spectrometry (GC–MS). Finally, to identify potential molecular targets causing the phenotypic changes in leukemic cell lines, we docked a selected group of these essential oils to several key intracellular proteins. According to results of rank score algorithm, five of these essential oils analyzed might be considered as in silico plausible candidates to be used as antileukemic agents.
Item Type: Article
Uncontrolled Keywords: Algae; Essential oils; Leukemia; GC-MS
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Selim Çetiner
Date Deposited: 12 Nov 2016 16:30
Last Modified: 22 May 2019 13:44
URI: https://research.sabanciuniv.edu/id/eprint/30599

Actions (login required)

View Item
View Item