Cytotoxic effect of extract from Dunaliella salina against SH-SY5Y neuroblastoma cells

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Atasever Arslan, Belkıs and Yılancıoğlu, Kaan and Bekaroğlu, Maide G. and Taşkın, Emre and Altınöz, Eyup and Çetiner, Selim (2015) Cytotoxic effect of extract from Dunaliella salina against SH-SY5Y neuroblastoma cells. General Physiology and Biophysics, 34 (2). pp. 201-207. ISSN 0231-5882 (Print) 1338-4325 (Online)

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Abstract

Cytotoxic effects of essential oils extracted from Dunaliella sauna on SH-SY5Y human neuroblastoma cells were investigated in this study. GC-MS analysis was used for determination of the composition of essential oils found in Dunaliella salina extract. All experimented concentrations of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells were significantly more cytotoxic than the tested concentrations of the extract on ECV304 human endothelial cells used as a control. Fifthy compounds were detected in GC-MS analysis of the extract, and five major compounds were predominantly found as follows: octadecanoic acid, methyl ester (27.43%); hexadecanoic acid, methyl ester (Cas) methyl palmitate (24.82%); 9,12,15-octadecatrienoic acid, ethyl ester, (Z,Z,Z)- (7.39%); octadecanoic acid (5.03%), pentadecanoic acid (3.60%). The cytotoxic activity of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells might be due to high concentrations of octadecanoic acid and hexadecanoic acid. Furthermore, results indicate that the extract demonstrates some proliferative effect on ECV304 cells in a dose-dependent manner between 0.25 and 5 mu g/ml. These results suggest that Dunaliella sauna may have anticancer potential against human neuroblastoma cells.
Item Type: Article
Uncontrolled Keywords: Algae; Cytotoxicity; Dunaliella salina; Essential oil; SH-SY5Y human neuroblastoma cells
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Selim Çetiner
Date Deposited: 23 Dec 2015 15:39
Last Modified: 26 Apr 2022 09:28
URI: https://research.sabanciuniv.edu/id/eprint/28521

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