Spatially multi-functional porous tissue scaffold

Khoda, AKM Bashirul and Özbolat, İbrahim T. and Koç, Bahattin (2013) Spatially multi-functional porous tissue scaffold. In: 3rd ECCOMAS Thematic Conference on Tissue Engineering (ICTE), Leiria, Portugal

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A novel tissue scaffold design technique has been proposed with controllable heterogeneous architecture design suitable for additive manufacturing processes. The proposed layer-based design uses a bi-layer pattern of radial and spiral layer consecutively to generate functionally gradient porosity, which follows the geometric shape of the scaffold. The proposed approach constructs the medial region from the medial axis of each corresponding layer. The radial layers of the scaffold are then generated by connecting the boundaries of the medial region and the layer's outer contour. Gradient porosity is changed between the medial region and the layer's outer contour. Iso-porosity regions are determined by dividing the sub-regions peripherally into pore cells and consecutive iso-porosity curves are generated using the iso-points from those pore cells. The combination of consecutive layers generates the pore cells with desired pore sizes. To ensure the fabrication of the designed scaffolds, the generated contours are optimized for a continuous, interconnected, and smooth deposition path-planning. The proposed methodologies can generate the structure with gradient (linear or non-linear), variational or constant porosity that can provide localized control of variational porosity along the scaffold architecture. The designed porous structures can be fabricated using additive Manufacturing processes.
Item Type: Papers in Conference Proceedings
Uncontrolled Keywords: Multifunctional tissue scafolds; tissue engineering; bioadditive manufacturing
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Industrial Engineering
Sabancı University Nanotechnology Research and Application Center
Faculty of Engineering and Natural Sciences > Academic programs > Manufacturing Systems Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Bahattin Koç
Date Deposited: 18 Jan 2014 12:39
Last Modified: 26 Apr 2022 09:13

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