Hybrid tissue scaffolds for controlled release applications

Özbolat, İbrahim T. and Khoda, A.K.M.B. and Marchany, Michelle and Gardella, Joseph A. and Koç, Bahattin (2012) Hybrid tissue scaffolds for controlled release applications. Virtual and Physical Prototyping, 7 (1). pp. 37-47. ISSN 1745-2759 (Print) 1745-2767 (Online)

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Spatiotemporal delivery of incorporated biological modifiers from synthesised tissue scaffolds has higher speculation to stimulate the complex tissue regeneration process via controlling the extracellular matrix. In this research, we consider the matrix material degradation profile, impregnated biological modifier and permeability of the structure to build hybrid tissue scaffolds based on tissue engineering requirements. Such hybrid structures are modelled, designed and fabricated to control release kinetics spatiotemporally for guided tissue regeneration. Firstly, a computer-aided biodegradation model is developed to simulate the degradation process of micro-patterned polymeric scaffolds. Secondly, scaffolds are biomimetically designed to control internal porous architecture with varying porosity. An optimised internal architecture scheme is developed to enhance permeability i.e. fluid transport to mediate release kinetics through the internal regions. Thirdly, heterogeneous scaffolds are developed with control composition of biomaterials and biological modifiers to synchronise the release kinetics with tissue regeneration. Proposed methods are implemented and illustrative examples are presented.
Item Type: Article
Uncontrolled Keywords: controlled release, engineered tissue scaffolds, solid freeform fabrication
Subjects: R Medicine > R Medicine (General) > R856-857 Biomedical engineering. Electronics. Instrumentation
T Technology > TP Chemical technology > TP0248.13 Biotechnology
R Medicine > R Medicine (General) > R858-859.7 Computer applications to medicine. Medical informatics
Divisions: Faculty of Engineering and Natural Sciences
Faculty of Engineering and Natural Sciences > Academic programs > Manufacturing Systems Eng.
Depositing User: Bahattin Koç
Date Deposited: 02 Dec 2012 14:06
Last Modified: 31 Jul 2019 16:29
URI: https://research.sabanciuniv.edu/id/eprint/20931

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