A new approach for improving coronary plaque component analysis based on intravascular ultrasound images

Taki, Arash and Hetterich, Holger and Roodaki, Alireza and Setarehdan, S. K. and Ünal, Gözde and Rieber, Johannes and Navab, Nassir and König, Andreas (2010) A new approach for improving coronary plaque component analysis based on intravascular ultrasound images. Ultrasound in Medicine and Biology, 36 (8). pp. 1245-1258. ISSN 0301-5629

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Virtual histology intravascular ultrasound (VH-IVUS) is a clinically available technique for atherosclerosis plaque characterization. It, however, suffers from a poor longitudinal resolution due to electrocardiogram (ECG)-gated acquisition. This article presents an effective algorithm for IVUS image-based histology to overcome this limitation. After plaque area extraction within an input IVUS image, a textural analysis procedure consisting of feature extraction and classification steps is proposed. The pixels of the extracted plaque area excluding the shadow region were classified into one of the three plaque components of fibro-fatty (FF), calcification (CA) or necrotic core (NC) tissues. The average classification accuracy for pixel and region based validations is 75% and 87% respectively. Sensitivities (specificities) were 79% (85%) for CA, 81% (90%) for FF and 52% (82%) for NC. The kappa (kappa) = 0.61 and p value = 0.02 indicate good agreement of the proposed method with VH images. Finally, the enhancement in the longitudinal resolution was evaluated by reconstructing the IVUS images between the two sequential IVUS-VH images.
Item Type: Article
Uncontrolled Keywords: IVUS; Plaque component analysis; Shadow region; Longitudinal resolution; Virtual histology
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Q Science > QC Physics
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Electronics
Faculty of Engineering and Natural Sciences
Depositing User: Gözde Ünal
Date Deposited: 14 Sep 2010 11:52
Last Modified: 25 Jul 2019 13:59
URI: https://research.sabanciuniv.edu/id/eprint/14348

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