Preparation and characterization of nanoclay-hydrogel composite support-bath for bioprinting of complex structures
Afghah, Seyedeh Ferdows and Altunbek, Mine and Dikyol, Caner and Koç, Bahattin (2020) Preparation and characterization of nanoclay-hydrogel composite support-bath for bioprinting of complex structures. Scientific Reports, 10 (1). ISSN 2045-2322
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Official URL: http://dx.doi.org/10.1038/s41598-020-61606-x
Three-dimensional bioprinting of cell-laden hydrogels in a sacrificial support-bath has recently emerged as a potential solution for fabricating complex biological structures. Physical properties of the support-bath strongly influence the bioprinting process and the outcome of the fabricated constructs. In this study, we reported the application of a composite Pluronic-nanoclay support-bath including calcium ions as the crosslinking agent for bioprinting of cell-laden alginate-based hydrogels. By tuning the rheological properties, a shear-thinning composite support-bath with fast self-recovery behavior was yielded, which allowed continuous printing of complex and large-scale structures. The printed structures were easily and efficiently harvested from the support-bath without disturbing their shape fidelity. Moreover, the results showed that support-bath assisted bioprinting process did not influence the viability of cells encapsulated within hydrogel. This study demonstrates that Pluronic-nanoclay support-bath can be utilized for bioprinting of complex, cell-laden constructs for vascular and other tissue engineering applications.
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