3D-printed composite bone bricks for large bone tissue applications
Daskalakis, Evangelos and Liu, Fengyuan and Acar, Anıl Ahmet and Dinea, Edera-Elena and Cooper, Glen and Weightman, Andrew and Koç, Bahattin and Blunn, Gordon and Bártolo, Paulo Jorge (2020) 3D-printed composite bone bricks for large bone tissue applications. In: 7th International Conference of Materials and Manufacturing Engineering (ICMMEN 2020), Thessaloniki, Greece
Official URL: http://dx.doi.org/10.1051/matecconf/202031801009
This study investigates the use of low cost, customizable, biodegradable, polymer-ceramic composite porous structures (bone bricks) for large bone tissue regeneration. Different ceramic materials (hydroxyapatite (HA), β-tri-calcium phosphate (TCP) and Bioglass (45S5) were mixed with poly-ε-caprolactone (PCL). Bone bricks with different material compositions were produced using an extrusion-based additive manufacturing system. Produced bone bricks were morphologically and mechanically assessed. Results allowed to establish a correlation between scaffolds architecture and material composition and scaffolds performance. Reinforced scaffolds showed improved mechanical properties. Best mechanical properties were obtained with PCL/TCP bone bricks and topologies based on 38 double zig zag filaments and 14 spirals.
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