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MicroRNAs as major regulators of the autophagy pathway

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Akkoç, Yunus and Gözüaçık, Devrim (2020) MicroRNAs as major regulators of the autophagy pathway. Biochimica et Biophysica Acta - Molecular Cell Research, 1867 (5). ISSN 0167-4889 (Print) 1879-2596 (Online)

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Official URL: http://dx.doi.org/10.1016/j.bbamcr.2020.118662

Abstract

Autophagy is a cellular stress response mechanism activation of which leads to degradation of cellular components, including proteins as well as damaged organelles in lysosomes. Defects in autophagy mechanisms were associated with several pathologies (e.g. cancer, neurodegenerative diseases, and rare genetic diseases). Therefore, autophagy regulation is under strict control. Transcriptional and post-translational mechanisms that control autophagy in cells and organisms studied in detail. Recent studies introduced non-coding small RNAs, and especially microRNAs (miRNAs) in the post-translational orchestration of the autophagic activity. In this review article, we analyzed in detail the current status of autophagy-miRNA connections. Comprehensive documentation of miRNAs that were directly involved in autophagy regulation resulted in the emergence of common themes and concepts governing these complex and intricate interactions. Hence, a better and systematic understanding of these interactions reveals a central role for miRNAs in the regulation of autophagy.

Item Type:Article
Uncontrolled Keywords:MicroRNA; Autophagy; Mammalian autophagy regulation; Post-transcriptional control
Subjects:R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
ID Code:39817
Deposited By:Yunus Akkoç
Deposited On:21 Apr 2020 16:36
Last Modified:21 Apr 2020 16:36

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