Synthesis, characterization, and biological properties of composites of hydroxyapatite and hexagonal boron nitride
Ünal, Semra and Ekren, Nazmi and Sengil, Ahmet Z. and Oktar, Faik N. and Irmak, Ster and Kutlu, Özlem and Şahin, Yeşim M. and Kılıç, Osman and Agathopoulos, Simeon and Gündüz, Oğuzhan (2017) Synthesis, characterization, and biological properties of composites of hydroxyapatite and hexagonal boron nitride. Journal of Biomedical Materials Research Part B: Applied Biomaterials . ISSN 1552-4973 (Print) 1552-4981 (Online) Published Online First http://dx.doi.org/10.1002/jbm.b.34046
Official URL: http://dx.doi.org/10.1002/jbm.b.34046
Hydroxyapatite (HA), obtained from bovine bones,was successfully reinforced with hexagonal boron nitrite (h-BN). h-BN/HA composites, with BN content up to 1.5 wt %,were sintered at various temperatures between 1000 and13008C, in air. Well-sintered samples were obtained after sin-tering at 1200 and 13008C. The presence of h-BN contributedto dense, fine, and well-crystallized microstructure. Theresults of X-ray diffraction analysis and FT-IR spectroscopyshowed that the produced composites comprised biphasic b-TCP/HCA (HCA: carbonate partially substituted HA). High val-ues of mechanical properties were achieved, namelycompression strength 155 MPa for the sample 0.5% h-BN/HAand Vickers microhardness of 716 HV for the samples 1.5% h-BN/HA, both sintered at 13008C. U2OS human bone osteosar-coma proliferation and cell viability showed no adverse effectin the presence of h-BN/HA, suggesting the potential use ofthe produced materials as safe biomaterials in bone tissueengineering.
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