Capacitive biosensor for nanotoxicity detection

Qureshi, Anjum and Gürbüz, Yaşar and Kolkar Mohammed, Javed Hussain Niazi (2012) Capacitive biosensor for nanotoxicity detection. (Accepted/In Press)

WarningThere is a more recent version of this item available.

[img]PDF - Repository staff only - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader

Official URL: http://www.elsevier.com/journals/procedia-engineering/1877-7058


Nanomaterials (NMs) are widely used in health and biomedical applications, however, only a few studies investigated their toxic effects. Here, we have developed a capacitive biosensor to detect toxic effects of NMs using whole E. coli cells as biological reporters and gold nanoparticles (AuNPs) as models. The results showed that capacitive response was dependent on the size of nanoparticles. The toxic effect of nanoparticles was also studied using attenuated total reflection-fourier transform infrared (ATR-FTIR) spectra and scanning electron microscopy (SEM). Our results showed that it is possible to detect toxic effects of nanoparticles on E. coli cells by the developed capacitive biosensor. The toxic effects is attributed to the damage of the cells’ outer membrane in combination with AuNP’s byproducts, such as free radicals and reactive oxygen species (ROS) entering the cells. The methodology developed has a great potential to be applied in nanotechnology for classifying toxic and non-toxic NMs.

Item Type:Article
Uncontrolled Keywords:Biosensor, nanotoxicity, bacteria
Subjects:T Technology > TK Electrical engineering. Electronics Nuclear engineering
ID Code:19965
Deposited By:Javed Kolkar
Deposited On:03 Nov 2012 20:16
Last Modified:31 Jul 2019 14:07

Available Versions of this Item

Repository Staff Only: item control page