A new microfluidics system with a hand-operated, on-chip actuator for immunosensor applications

Warning The system is temporarily closed to updates for reporting purpose.

Kallempudi, Sreenivasa Saravan and Altıntaş, Zeynep and Kolkar Mohammed, Javed Hussain Niazi and Gürbüz, Yaşar (2012) A new microfluidics system with a hand-operated, on-chip actuator for immunosensor applications. Sensors and Actuators B: Chemical, 163 (1). pp. 194-201. ISSN 0925-4005

Full text not available from this repository.

Official URL: http://dx.doi.org/10.1016/j.snb.2012.01.034


This paper presents the realization of a portable, point-of-care and multi-target immunosensing lab-on-a-chip (LOC). The chip utilizes a novel on-chip actuating mechanism which uses a negative pressure to create thrust inside the channels to facilitate and control the fluid flow. No external instruments and/or sources were used to drive or control the liquid throughout the experimentation. LOC demonstrates a highly sensitive detection and quantification of a cancer marker, human-epidermal growth factor receptor (hEGFR) and a cardiac marker, interleukin 6 (IL-6) by impedimetric measurement approach. Without the use of any signal amplification methods (chemical), a dynamic detection limit of 3-8 ng/ml of hEGFR and 0.1-5 ng/ml of IL-6 in human serum was obtained. The extracted dissociation constants were calculated as 5.86 ng/ml (hEGFR) and 2.45 ng/ml (IL-6) by kinetic analysis.

Item Type:Article
Uncontrolled Keywords:Biosensor; Immunosensor; Cancer marker detection; Cardiovascular disease marker detection; Lab-on-a-Chip
Subjects:R Medicine > R Medicine (General) > R856-857 Biomedical engineering. Electronics. Instrumentation
Q Science > QD Chemistry
ID Code:18974
Deposited By:Yaşar Gürbüz
Deposited On:06 Apr 2012 11:55
Last Modified:31 Jul 2019 10:47

Repository Staff Only: item control page