Genome rearrangement: a planning approach

Uras, Tansel and Erdem, Esra (2010) Genome rearrangement: a planning approach. In: The 24th AAAI Conference on Artificial Intelligence (AAAI-10), Atlanta, Georgia, USA

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Official URL: http://www.aaai.org/ocs/index.php/AAAI/AAAI10/paper/view/1664/2324


Evolutionary trees of species can be reconstructed by pairwise comparison of their entire genomes. Such a comparison can be quantified by determining the number of events that change the order of genes in a genome. Earlier Erdem and Tillier formulated the pairwise comparison of entire genomes as the problem of planning rearrangement events that transform one genome to the other. We reformulate this problem as a planning problem to extend its applicability to genomes with multiple copies of genes and with unequal gene content, and illustrate its applicability and effectiveness on three real datasets: mitochondrial genomes of Metazoa, chloroplast genomes of Campanulaceae, chloroplast genomes of various land plants and green algae.

Item Type:Papers in Conference Proceedings
ID Code:15348
Deposited By:Esra Erdem
Deposited On:25 Nov 2010 22:13
Last Modified:29 Jul 2019 11:43

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