Production of the biomimetic small diameter blood vessels for cardiovascular tissue engineering
Aydoğdu, Mehmet Onur and Chou, Joshua and Altun, Esra and Ekren, Nazmi and Çakmak, Selami and Eroğlu, Mehmet and Osman, Asıla A. and Kutlu, Özlem and Toksoy Öner, Ebru and Avşar, Gülben and Oktar, Faik Nüzhet and Yılmaz, İsmail and Gündüz, Oğuzhan (2019) Production of the biomimetic small diameter blood vessels for cardiovascular tissue engineering. International Journal of Polymeric Materials and Polymeric Biomaterials, 68 (5). pp. 243-255. ISSN 0091-4037 (Print) 1563-535X (Online)
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Official URL: http://dx.doi.org/10.1080/00914037.2018.1443930
A novel biomimetic vascular graft scaffolds were produced by electrospinning method with the most superior characteristics to be a proper biomimetic small diameter blood vessel using Polycaprolactone(PCL), Ethyl Cellulose(EC) and Collagen Type-1 were used to create the most convenient synergy of a natural and synthetic polymer to achieve similarity to native small diameter blood vessels. Scanning Electron Microscopy(SEM), Fourier Transform Infrared Spectroscopy(FTIR), Differential Scanning Calorimetry Analysis(DSC), tensile measurement tests, and in-vitro and in-vivo applications were performed. Results indicated significant properties such as having 39.33 nm minimum, 104.98 nm average fiber diameter, 3.2 MPa young modulus and 135% relative cell viability.
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