title   
  

Gene delivery by hydroxyapatite and calcium phosphate nanoparticles: a review of novel and recent applications

Warning The system is temporarily closed to updates for reporting purpose.

Bakan, Feray (2018) Gene delivery by hydroxyapatite and calcium phosphate nanoparticles: a review of novel and recent applications. In: Thirumalai, Jagannathan, (ed.) Hydroxyapatite: Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets. IntechOpen, London, UK, pp. 157-176. ISBN 978-953-51-3804-4 (Print) 978-953-51-3805-1 (Online)

[img]
Preview
PDF (book chapter) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
4Mb

Official URL: http://dx.doi.org/10.5772/intechopen.71062

Abstract

Gene therapy is a targeted therapy which can be used in the treatment of various acquired and inherited diseases. Inhabitation of a gene function, restoring or improving a gene, or gaining a new function can be achieved by gene therapy strategies. The most crucial step in this therapy is delivering the therapeutic material to the target. Nanosized calcium phosphates (CaPs) have been considered as promising carriers due to their excellent biocompatibility. In this chapter, the delivery of DNA, siRNA, and miRNA by using CaP nanocarriers were compiled in detail and the main parameters which can affect the carrier properties and thus the gene transfer efficiency were also discussed.

Item Type:Book Section / Chapter
Subjects:Q Science > Q Science (General)
R Medicine > RM Therapeutics. Pharmacology
ID Code:35722
Deposited By:Feray Bakan
Deposited On:12 Aug 2018 20:47
Last Modified:22 May 2019 14:08

Repository Staff Only: item control page