Gene delivery by hydroxyapatite and calcium phosphate nanoparticles: a review of novel and recent applications
Bakan, Feray (2018) Gene delivery by hydroxyapatite and calcium phosphate nanoparticles: a review of novel and recent applications. In: Thirumalai, Jagannathan, (ed.) Hydroxyapatite: Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets. IntechOpen, London, UK, pp. 157-176. ISBN 978-953-51-3804-4 (Print) 978-953-51-3805-1 (Online)
Official URL: http://dx.doi.org/10.5772/intechopen.71062
Gene therapy is a targeted therapy which can be used in the treatment of various acquired and inherited diseases. Inhabitation of a gene function, restoring or improving a gene, or gaining a new function can be achieved by gene therapy strategies. The most crucial step in this therapy is delivering the therapeutic material to the target. Nanosized calcium phosphates (CaPs) have been considered as promising carriers due to their excellent biocompatibility. In this chapter, the delivery of DNA, siRNA, and miRNA by using CaP nanocarriers were compiled in detail and the main parameters which can affect the carrier properties and thus the gene transfer efficiency were also discussed.
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