Probing synergistic toxicity effects on living cells by combination of two different sized nanoparticles by a whole-cell based biochip
Pandey, Ashish and Gürbüz, Yaşar and Özgüz, Volkan Hüsnü and Kolkar Mohammed, Javed Hussain Niazi and Qureshi, Anjum (2017) Probing synergistic toxicity effects on living cells by combination of two different sized nanoparticles by a whole-cell based biochip. In: International Conference on Advancements in Aeromechanical Materials for Manufacturing (ICAAMM), MLR Institute of Technology, Hyderabad, Telangana, India
Official URL: http://dx.doi.org/10.1016/j.matpr.2017.07.187
In this study, a whole-cell based capacitive sensor chip was employed to determine the toxicity effects caused by pure and mixed combinations of TiO2 and Fe3O4 nanoparticles (NPs). Our results demonstrated that the cells-on-chip severely affected by the exposure of pure forms of NPs, while a synergistic effect occurred with significantly less toxicity when TiO2:Fe3O4 combinations were used. The toxic effects with pure forms of NPs are attributed to disorganization of cell-surface charges dominated as compared to exposure of mixed combinations of NPs. The developed whole-cell chip offered real-time, label-free and non-invasive detection tool for probing cellular responses against NPs.
Repository Staff Only: item control page