Biomanufacturing of heterogeneous hydrogel structures with patterned electrically conductive regions
Nadernezhad, Ali and Khani, Navid and Koç, Bahattin (2017) Biomanufacturing of heterogeneous hydrogel structures with patterned electrically conductive regions. In: 3rd CIRP Conference on BioManufacturing, Chicago, USA
Official URL: http://dx.doi.org/10.1016/j.procir.2017.04.019
In this paper, we present the biomanufacturing of patterned electrically conductive and cell- embedded hydrogel structures, in which selectively patterned regions of hydrogels including carbon nanotubes (CNTs) and NIH 3T3 cells were demonstrated. We employed a recently developed method of multimaterial additive manufacturing of hydrogels, by using an aspiration-on-demand protocol. The printed structures were characterized by electrical resistivity measurements and microscopy techniques. The results showed that by selectively patterning the electrical conductivity, each region can be considered as a resistor in series circuit. Moreover, due to the novel approach in assembly of cell-patterned segments in low viscosity, the cell viability in printed structures was high after printing. The prospects of combining the functionalities of two fabricated structures were further discussed and highlighted.
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