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Physiological and pathological significance of the molecular cross-talk between autophagy and apoptosis

Oral, Özlem and Akkoç, Yunus and Bayraktar, Öznur and Gözüaçık, Devrim (2016) Physiological and pathological significance of the molecular cross-talk between autophagy and apoptosis. Histology and Histopathology, 31 (5). pp. 479-498. ISSN 0213-3911 (Print) 1699-5848 (Online)

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Abstract

Autophagy and apoptosis are two important molecular mechanisms that maintain cellular homeostasis under stress conditions. Autophagy represents an intracellular mechanism responsible for turnover of organelles and long-lived proteins through a lysosome-dependent degradation pathway. Cell death signals or sustained stress might trigger programmed cell death pathways, and among them, apoptosis is the most extensively studied one. Recent studies indicate the presence of a complex interplay between autophagy and apoptosis. Physiological relevance of autophagy-apoptosis crosstalk was mainly shown in vitro. However, in vivo consequences possibly exist both during health and disease. In this review, we will summarize the current knowledge about molecular mechanisms connecting autophagy and apoptosis, and about the significance of this crosstalk for human health.

Item Type:Article
Additional Information:WoS Document Type: Review
Uncontrolled Keywords:Autophagy; Apoptosis; Signaling; Cross-talk; Diseases
Subjects:Q Science > Q Science (General)
ID Code:29430
Deposited By:Özlem Oral
Deposited On:03 Aug 2016 12:21
Last Modified:03 Aug 2016 12:21

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