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Oxysterols and mechanisms of survival signaling

Vuruşaner Aktaş, Beyza and Leonarduzzi, Gabriella and Gamba, Paola and Poli, Giuseppe and Başağa, Hüveyda (2016) Oxysterols and mechanisms of survival signaling. (Accepted/In Press)

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Official URL: http://dx.doi.org/10.1016/j.mam.2016.02.004

Abstract

Oxysterols, a family of oxidation products of cholesterol, are increasingly drawing attention of scientists to their multifaceted biochemical properties, several of them of clear relevance to human pathophysiology. Taken up by cells through both vesicular and nonvesicular ways or often generated intracellularly, oxysterols contribute to modulate not only the inflammatory and immunological response but also cell viability, metabolism and function by modulating several signaling pathways. Moreover, they have been recognized as elective ligands for the most important nuclear receptors. The outcome of such a complex network of intracellular reactions promoted by these cholesterol oxidation products appears to be largely dependent not only on the type of cells, the dynamic conditions of the cellular and tissue environment but also on the concentration of the oxysterols. Here focus has been given to the cascade of molecular events exerted by relatively low concentrations of certain oxysterols that elicit survival and functional signals in the cells, with the aim to contribute to further expand the knowledge about the biological and physiological potential of the biochemical reactions triggered and modulated by oxysterols.

Item Type:Article
Uncontrolled Keywords:Oxysterols; Survival; Nrf2; Autophagy
Subjects:Q Science > Q Science (General)
R Medicine > R Medicine (General)
ID Code:29235
Deposited By:Beyza Vuruşaner Aktaş
Deposited On:18 Apr 2016 11:24
Last Modified:03 Nov 2016 15:33

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