3D hybrid wound devices for spatiotemporally controlled release kinetics
Özbolat, İbrahim T. and Koç, Bahattin (2012) 3D hybrid wound devices for spatiotemporally controlled release kinetics. Computer Methods and Programs in Biomedicine, 108 (3). pp. 922-931. ISSN 0169-2607 (Print) 1872-7565 (Online)
Official URL: http://dx.doi.org/10.1016/j.cmpb.2012.05.004
This paper presents localized and temporal control of releasekinetics over 3-dimensional (3D) hybridwounddevices to improve wound-healing process. Imaging study is performed to extract wound bed geometry in 3D. Non-Uniform Rational B-Splines (NURBS) based surface lofting is applied to generate functionally graded regions. Diffusion-based releasekinetics model is developed to predict time-based release of loaded modifiers for functionally graded regions. Multi-chamber single nozzle solid freeform dispensing system is used to fabricate wounddevices with controlled dispensing concentration. Spatiotemporal control of biological modifiers thus enables a way to achieve target delivery to improve wound healing.
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