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Capacitive biosensor for nanotoxicity detection

Qureshi, Anjum and Gürbüz, Yaşar and Kolkar Mohammed, Javed Hussain Niazi (2012) Capacitive biosensor for nanotoxicity detection. In: 26th European Conference on Solid-State Transducers (EUROSENSOR 2012), Kraków, Poland

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Official URL: http://dx.doi.org/10.1016/j.proeng.2012.09.401

Abstract

Nanomaterials (NMs) are widely used in health and biomedical applications, however, only a few studies investigated their toxic effects. Here, we have developed a capacitive biosensor to detect toxic effects of NMs using whole E. coli cells as biological reporters and gold nanoparticles (AuNPs) as models. The results showed that capacitive response was dependent on the size of nanoparticles. The toxic effect of nanoparticles was also studied using attenuated total reflection-fourier transform infrared (ATR-FTIR) spectra and scanning electron microscopy (SEM). Our results showed that it is possible to detect toxic effects of nanoparticles on E. coli cells by the developed capacitive biosensor. The toxic effects is attributed to the damage of the cells’ outer membrane in combination with AuNP’s byproducts, such as free radicals and reactive oxygen species (ROS) entering the cells. The methodology developed has a great potential to be applied in nanotechnology for classifying toxic and non-toxic NMs.

Item Type:Papers in Conference Proceedings
Uncontrolled Keywords:Lab-on-a-chip; biosensor; nanotoxicity; nanomaterial; E. coli
Subjects:Q Science > Q Science (General)
T Technology > TK Electrical engineering. Electronics Nuclear engineering
ID Code:20666
Deposited By:Javed Hussain Niazi Kolkar Mohammed
Deposited On:05 Dec 2012 14:11
Last Modified:01 Mar 2014 18:25

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