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Autophagy in urology (Ürolojide otofaji)

Oral, Özlem and Irmak, Ster and Ekici, Sinan and Gözüaçık, Devrim (2012) Autophagy in urology (Ürolojide otofaji). In: Türkeri, Levent and Özer, Ayşe and Narter, Fehmi, (eds.) Moleküler Üroloji. Moleküler Üroloji: Ürolojik Hastalıkların Moleküler Temeli. Üroonkoloji Derneği Yayınları, İstanbul, pp. 271-283. ISBN 978-975-01697-2-4

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Abstract

Autophagy is an evolutionary conserved physiological event. It regulates intracellular homeostasis through recycling of cellular organelles and long-lived proteins. Autophagy is rapidly activated under stress conditions such as starvation and growth factor deprivation and supplies necessary components for the survival of cells. Thus, autophagy plays a role as a pro-survival phenomenon under certain conditions. On the other hand in some cases, autophagy pathways are involved in a caspase-independent, non-apoptotic cell death program called “autophagic cell death”. Studies in the last decade revealed the involvement of autophagy in several physiological and pathological events, establishing it as a new and important field of research for both basic scientists and clinicians. In this chapter, the effects of autophagy and -related molecular events in the development, progress and treatment of the urinary system diseases will be discussed.

Item Type:Book Section / Chapter
Additional Information:DG is the corresponding author
Uncontrolled Keywords:Urological Disease, urinary system, autophagy, cell, stress, apoptosis, programmed cell death, survival, signal transduction.
Subjects:Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RB Pathology
Q Science > QL Zoology
Q Science > QP Physiology
ID Code:20179
Deposited By:Devrim Gözüaçık
Deposited On:30 Nov 2012 15:06
Last Modified:30 Nov 2012 15:06

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