Identification of transcription factor binding sites in promoter databases
Durası, İlknur Melis and Dağ, Uğur and Güngör, Burcu Bakır and Erdoğan, Burcu and Kurnaz, Işıl Aksan and Sezerman, Uğur (2011) Identification of transcription factor binding sites in promoter databases. In: 6th International Symposium on Health Informatics and Bioinformatics, (HIBIT 2011), Izmir, Turkey
Transcription factors (TFs) are the proteins which regulates the expression of their target genes either in a positive or negative manner. TFs realize this task by binding to a specific DNA sequence contained in promoter regions, via their DNA binding motifs. Among ETS family TFs, Pea3 proteins are involved in the regulation of expression of genes, which are important for cell growth, development, differentiation, oncogenic transformation and apoptosis. In silico studies should be done to find out the novel target genes for this TF. Even though a few bioinformatics tools are available for this purpose, the user needs to go back and forth between different tools, and to repeat these steps for each of their candidate gene. Here we combined these tools and constituted a new tool which examines the affinity of any TF towards the selected target genes’ promoter sequences. The tool is tested on several genes, which are predicted to be regulated by Pea3 TF.
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