A new nanocrystalline diamond-based biosensor for the detection of cardiovascular risk markers
Qureshi, Anjum and Kallempudi, S. Saravan and Gürbüz, Yaşar and Howell, Mick and Kang, Weng P. and Davidson, Jimmy L. (2009) A new nanocrystalline diamond-based biosensor for the detection of cardiovascular risk markers. In: 23rd Eurosensors Conference, Lausanne, Switzerland
Official URL: http://dx.doi.org/10.1016/j.proche.2009.07.269
In this paper, a new method to probe associative interactions of C-reactive protein (CRP) antigen with CRP antibody immobilized on a gold-interdigitated diamond electrodes was investigated. The CRP antigen detection was performed by capacitive/dielectric-constant measurements. Our results showed that the dynamic detection range using optimized conditions for a given antibody concentration (100 μg/ml) was found to be in the range 25-800 ng/ml of CRP-antigen. Biosensor developed in this study can be potentially used for detection of elevated CRP levels in suspected subjects for early diagnosis.
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