Evaluation and validation of synergistic effects of amyloid-beta inhibitor-gold nanoparticles complex on Alzheimer's disease using deep neural network approach

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Kaushik, Aman Chandra and Kumar, Ajay and Peng, Zhennan and Khan, Abbas and Junaid, Muhammad and Ali, Arif and Bharadwaj, Shiv Kumar and Wei, Dong Qing (2019) Evaluation and validation of synergistic effects of amyloid-beta inhibitor-gold nanoparticles complex on Alzheimer's disease using deep neural network approach. Journal of Materials Research, 34 (11). pp. 1845-1853. ISSN 0884-2914 (Print) 2044-5326 (Online)

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Abstract

Numerous studies have reported that amyloid-beta 42 (Aβ-42) protein is a high-profile risk factor associated with the onset and progression of Alzheimer's disease (AD). Accumulation of extracellular senile plaques, synaptic degeneration, and intracellular neurofibrillary tangles were recorded as essential features that facilitate the onset of Aβ-42, resulting in AD. Hence, we attempted a new screening technique to discover potential inhibitors against Aβ-42 using an in silico deep neural network approach. We screened PubChem compounds library and found wgx-50 as a potential inhibitor of Aβ-42. Also, synergistic effects of wgx-50-gold nanoparticles (AuNPs) complex induced significant inhibition of Aβ-42, compared with those of wgx-50 alone. Further, molecular docking analysis, systems biology approach, and time course simulation confirmed that synergistic effects of wgx-50-AuNPs complex have potential application in the treatment for AD. Additionally, we proposed the biological circuit for AD induced by Aβ-42 that can be used to monitor the effect of drugs on AD.
Item Type: Article
Uncontrolled Keywords: Alzheimer's disease; amyloid-beta 42; AuNP; biochemical pathway
Divisions: Sabancı University Nanotechnology Research and Application Center
Depositing User: Shiv Kumar Bharadwaj
Date Deposited: 18 Jul 2023 14:40
Last Modified: 18 Jul 2023 14:40
URI: https://research.sabanciuniv.edu/id/eprint/46123

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