Miniaturized checkerboard assays to measure antibiotic interactions

Çakmak, Melike Çokol and Cokol, Murat (2019) Miniaturized checkerboard assays to measure antibiotic interactions. In: Larson, Richard S. and Oprea, Tudor I., (eds.) Bioinformatics and Drug Discovery. Methods in Molecular Biology, 1939. Humana Press, New York, NY, pp. 3-9. ISBN 978-1-4939-9088-7 (Print) 978-1-4939-9089-4 (Online)

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Drugs may have synergistic or antagonistic interactions when combined. Checkerboard assays, where two drugs are combined in many doses, allow sensitive measurement of drug interactions. Here, we describe a protocol to measure the pairwise interactions among three antibiotics, in duplicate, in 5 days, using only two 96-well microplates and standard laboratory equipment.
Item Type: Book Section / Chapter
Uncontrolled Keywords: Checkerboard assay; Drug interactions; Drug synergy
Divisions: Faculty of Engineering and Natural Sciences
Depositing User: Melike Çokol Çakmak
Date Deposited: 12 Jun 2023 15:22
Last Modified: 12 Jun 2023 15:22

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