Çakmak, Melike Çokol and Cokol, Murat (2019) Miniaturized checkerboard assays to measure antibiotic interactions. In: Larson, Richard S. and Oprea, Tudor I., (eds.) Bioinformatics and Drug Discovery. Methods in Molecular Biology, 1939. Humana Press, New York, NY, pp. 3-9. ISBN 978-1-4939-9088-7 (Print) 978-1-4939-9089-4 (Online)
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Official URL: https://dx.doi.org/10.1007/978-1-4939-9089-4_1
Abstract
Drugs may have synergistic or antagonistic interactions when combined. Checkerboard assays, where two drugs are combined in many doses, allow sensitive measurement of drug interactions. Here, we describe a protocol to measure the pairwise interactions among three antibiotics, in duplicate, in 5 days, using only two 96-well microplates and standard laboratory equipment.
| Item Type: | Book Section / Chapter |
|---|---|
| Uncontrolled Keywords: | Checkerboard assay; Drug interactions; Drug synergy |
| Divisions: | Faculty of Engineering and Natural Sciences |
| Depositing User: | Melike Çokol Çakmak |
| Date Deposited: | 12 Jun 2023 15:22 |
| Last Modified: | 12 Jun 2023 15:22 |
| URI: | https://research.sabanciuniv.edu/id/eprint/46020 |
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