Drug delivery (nano)platforms for oral and dental applications: tissue regeneration, infection control, and cancer management

Makvandi, Pooyan and Josic, Uros and Delfi, Masoud and Pinelli, Filippo and Jahed, Vahid and Kaya, Emine and Ashrafizadeh, Milad and Zarepour, Atefeh and Rossi, Filippo and Zarrabi, Ali and Agarwal, Tarun and Zare, Ehsan Nazarzadeh and Ghomi, Matineh and Kumar Maiti, Tapas and Breschi, Lorenzo and Tay, Franklin R. (2021) Drug delivery (nano)platforms for oral and dental applications: tissue regeneration, infection control, and cancer management. Advanced Science, 8 (8). ISSN 2198-3844

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The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically-administered medications, drug resistance and adverse side-effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle-containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug-release platforms than conventional treatment approaches. The present review provides an overview of newly-developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.
Item Type: Article
Uncontrolled Keywords: antibacterial; antiviral; drug delivery; oral cancer; tissue regeneration
Divisions: Faculty of Engineering and Natural Sciences
Sabancı University Nanotechnology Research and Application Center
Depositing User: Ali Zarrabi
Date Deposited: 03 Sep 2022 13:24
Last Modified: 03 Sep 2022 13:24
URI: https://research.sabanciuniv.edu/id/eprint/43400

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