Involvement of autophagy in T cell biology

Kutlu Oral, Özlem and Yedier, Özlem and Kılıç, Seval and Gözüaçık, Devrim (2017) Involvement of autophagy in T cell biology. Histology and Histopathology, 32 (1). pp. 11-20. ISSN 0213-3911 (Print) 1699-5848 (Online)

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Autophagy is an essential cellular pathway that sequesters various cytoplasmic components, including accumulated proteins, damaged organelles or invading microorganisms and delivers them to lysosomes for degradation. The function of autophagy has been reported in various tissues and systems, including its role in the regulation of cellular immunity. Autophagy plays a fundamental role at various stages of T cell maturation. It regulates the thymocyte selection and the generation of T cell repertoire by presenting intracellular antigens to MHC class molecules. Autophagy is crucial for metabolic regulation of T cells, and therefore supports cell survival and homeostasis, particularly in activated mature T cells. Furthermore, deletion of specific autophagy-related genes induces several immunological alterations including differentiation of activated T cells into regulatory, memory or natural killer T cells. In this review, we emphasize the impact of autophagy on T cell development, activation and differentiation, which is pivotal for the adaptive immune system.
Item Type: Article
Additional Information: Wos & Scopus Document Type: Review
Uncontrolled Keywords: Cancer; Autophagy; Cell death, T cells; Autophagy; T cells homeostasis; T cells function; Adaptive immune system
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Biological Sciences & Bio Eng.
Faculty of Engineering and Natural Sciences > Academic programs > Mechatronics
Faculty of Engineering and Natural Sciences
Depositing User: Devrim Gözüaçık
Date Deposited: 22 Aug 2017 15:04
Last Modified: 22 May 2019 13:55

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