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Effective neural photostimulation using indium-based type-II quantum dots

Bahmani Jalali, Houman and Aria, Mohammad Mohammadi and Dikbaş, Uğur Meriç and Sadeghi, Sadra and Kumar, Baskaran Ganesh and Şahin, Mehmet and Kavaklı, İbrahim Halil and Ow-Yang, Cleva W. and Nizamoğlu, Sedat (2018) Effective neural photostimulation using indium-based type-II quantum dots. Acs Nano, 12 (8). pp. 8104-8114. ISSN 1936-0851 (Print) 1936-086X (Online)

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Official URL: http://dx.doi.org/10.1021/acsnano.8b02976

Abstract

Light-induced stimulation of neurons via photoactive surfaces offers rich opportunities for the development of therapeutic methods and high-resolution retinal prosthetic devices. Quantum dots serve as an attractive building block for such surfaces, as they can be easily functionalized to match the biocompatibility and charge transport requirements of cell stimulation. Although indium-based colloidal quantum dots with type-I band alignment have attracted significant attention as a nontoxic alternative to cadmium-based ones, little attention has been paid to their photovoltaic potential as type-II heterostructures. Herein, we demonstrate type-II indium phosphide/zinc oxide core/shell quantum dots that are incorporated into a photoelectrode structure for neural photostimulation. This induces a hyperpolarizing bioelectrical current that triggers the firing of a single neural cell at 4 μW mm–2, 26-fold lower than the ocular safety limit for continuous exposure to visible light. These findings show that nanomaterials can induce a biocompatible and effective biological junction and can introduce a route in the use of quantum dots in photoelectrode architectures for artificial retinal prostheses.

Item Type:Article
Uncontrolled Keywords:biocompatible; indium phosphide; neural; photostimulation; quantum dot; type-II core/shell; zinc oxide
Subjects:UNSPECIFIED
ID Code:36550
Deposited By:Cleva W. Ow-Yang
Deposited On:06 Sep 2018 14:47
Last Modified:06 Sep 2018 14:47

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