Nanosilicate embedded agarose hydrogels with improved bioactivity

Topuz, Fuat and Nadernezhad, Ali and Çalışkan, Özüm Şehnaz and Menceloğlu, Yusuf Z. and Koç, Bahattin (2018) Nanosilicate embedded agarose hydrogels with improved bioactivity. (Accepted/In Press)

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Abstract

This paper reports the synthesis of nanocomposite agarose hydrogels with improved bioactivity with the incorporation of anisotropic 2D nanosilicates (Laponite) to promote cell binding, growth and proliferation. Rheological measurements showed that the incorporation of nanosilicates slightly increased the gelation temperature (Tgel). The use of higher nanosilicate content at the constant agarose concentration improved the mechanical properties of the gels. Due to the non-swelling nature of agarose, the nanosilicates did not cause any remarkable change in the swelling properties of the agarose gels, while collapsed agarose nanofibers were observed with the incorporation of nanosilicates. EDX analysis confirmed the presence of the embedded nanosilicates in the gel matrix. The existence of physical interactions between nanosilicate and agarose was demonstrated by FTIR over the shifting of Si-O stretching band to a lower frequency. The encapsulated NIH/3T3 fibroblast cells showed enhanced proliferation and spreading in the presence of nanosilicates.
Item Type: Article
Subjects: T Technology > TP Chemical technology > TP0248.13 Biotechnology
Divisions: Faculty of Engineering and Natural Sciences > Academic programs > Industrial Engineering
Sabancı University Nanotechnology Research and Application Center
Faculty of Engineering and Natural Sciences > Academic programs > Manufacturing Systems Eng.
Faculty of Engineering and Natural Sciences
Depositing User: Bahattin Koç
Date Deposited: 13 Aug 2018 22:21
Last Modified: 26 Apr 2022 09:59
URI: https://research.sabanciuniv.edu/id/eprint/36066

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