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Zn phthalocyanine conjugation to H2-ul aptamer for HER2-targeted breast cancer photodynamic therapy: Design, optimization and properties

Alpugan, Serkan and Derya, Topkaya and Aitlla, Devrim and Ahsen, Vefa and Kolkar Mohammed, Javed Hussain Niazi and Dumoulin, Fabienne (2017) Zn phthalocyanine conjugation to H2-ul aptamer for HER2-targeted breast cancer photodynamic therapy: Design, optimization and properties. Journal of Porphyrins and Phthalocyanines, 21 (12). pp. 887-892. ISSN 1088-4246 (Print) 1099-1409 (Online)

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Official URL: http://dx.doi.org/10.1142/S1088424617500973

Abstract

Tetrasulfonated Zn phthalocyanine was conjugated to a ssDNA aptamer moiety to produce a HER2 targeted photosensitizer. The tetraconjugate obtained was subjected to purification and the monoconjugate was successfully isolated, purified and characterized. This monoconjugate retained the ability to bind to HER2 as well as the potency to generate singlet oxygen.

Item Type:Article
Uncontrolled Keywords:cancer targeting; photodynamic therapy; HER2; aptamer; phthalocyanine
Subjects:R Medicine > R Medicine (General)
Q Science > QD Chemistry
ID Code:34288
Deposited By:Javed Hussain Niazi Kolkar Mohammed
Deposited On:26 Jun 2018 11:02
Last Modified:26 Jun 2018 11:02

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