title   
  

PMA functions as an autophagy inhibitor through activation of a serine threonine kinase

Yedier, Özlem and Kılıç, Seval and Gözüaçık, Devrim and Kutlu, Özlem (2017) PMA functions as an autophagy inhibitor through activation of a serine threonine kinase. In: VI. International Congress of Molecular Medicine, Istanbul, Turkey

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Abstract

Serine-threonine kinases have vital roles in various signalling pathways such as proliferation, differentiation and apoptosis. Thus, they served as crucial players in health and disease including cancer. Isozymes of these families show tissue specific expression patterns and function specifically in different pathways. Autophagy is another major process in the cell which degrades long-lived, non-functional organelles and proteins to sustain the homeostasis. Moreover, as well as serine threonine kinases, autophagy was also found to relate with cancer in different stages. To date, relationship between serine-threonine protein kinases and autophagy has not been well studied. Therefore, we utilized PMA which is one of the three different activatory signals of this kinase family to activate the certain subgroup and we studied the role of these kinases on autophagy regulation.

Item Type:Papers in Conference Proceedings
Subjects:UNSPECIFIED
ID Code:33610
Deposited By:Özlem Kutlu
Deposited On:14 Sep 2017 11:40
Last Modified:14 Sep 2017 11:40

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