Cell sheet as a bioink for 3D bioprinting
Bakırcı, Ezgi and Toprakhisar, Burak and Zeybek, Mehmet Can and İnce, Gözde and Koç, Bahattin (2016) Cell sheet as a bioink for 3D bioprinting. In: Towards Future Regenerative Therapies (TERMIS-EU 2016), Uppsala, Sweden
Cell sheet technology is a growing area in tissue engineering. It enables a sheet of interconnected cells which is enriched with cell-extracellular matrix (ECM) and cell-cell interactions. Poly (N-isopropylacrylamide) (PNIPAm) coating based thermoresponsive culture dishes are used as one of the advanced cell sheet technology methods . It allows the surface to demonstrate temperature responsive wettability changes in aqueous environments. Different methods can be used to fabricate PNIPAm surfaces such as initiated chemical vapor deposition (iCVD) which offers a control of the polymer thickness . In this research, we showed that thermoresponsive surfaces can create cell sheet which can be used as a bioink in 3D direct cell bioprinting . The aim of this work is to show that cell sheets can be used to increase mechanical strength of bioink.
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