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Thermally exfoliated graphene oxide reinforced fluorinated pentablock poly(l-lactide-co-ε-caprolactone) electrospun scaffolds: Insight into antimicrobial activity and biodegradation

Saner Okan, Burcu and Marset Castro, Azucena and Seyyed Monfared Zanjani, Jamal and Akkuş Sut, Pınar and Şen, Özlem and Çulha, Mustafa and Menceloğlu, Yusuf Z. (2016) Thermally exfoliated graphene oxide reinforced fluorinated pentablock poly(l-lactide-co-ε-caprolactone) electrospun scaffolds: Insight into antimicrobial activity and biodegradation. Journal of Applied Polymer Science, 133 (22). ISSN 0021-8995 (Print) 1097-4628 (Online)

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Official URL: http://dx.doi.org/10.1002/app.43490

Abstract

Three-dimensional fluorinated pentablock poly(l-lactide-co-ε-caprolactone)-based scaffolds were successfully produced by the incorporation of thermally exfoliated graphene oxide (TEGO) as an antimicrobial agent with an electrospinning technique. In a ring-opening polymerization, the fluorinated groups in the middle of polymer backbone were attached with a perfluorinated reactive stabilizer having oxygen-carrying ability. The fiber diameter and its morphologies were optimized through changes in TEGO amount, voltage, polymer concentration, and solvent type to obtain an ideal scaffold structure. Instead of the widely used graphene oxide synthesized by Hummer's method, TEGO sheets having a low amount of oxygen produced by thermal expansion were integrated into the fiber structure to investigate the effect of the oxygen functional groups of TEGO sheets on the degradation and antimicrobial activity of the scaffolds. There was no antimicrobial activity in TEGO-reinforced scaffolds in the in vitro tests in contrast to the literature. This study confirmed that a low number of oxygen functional groups on the surface of TEGO restricted the antimicrobial activity of the fabricated composite scaffolds.

Item Type:Article
Uncontrolled Keywords:biodegradable; copolymers; electrospinning; graphene and fullerenes; nanotubes; surfaces and interfaces
Subjects:T Technology > T Technology (General)
T Technology > TA Engineering (General). Civil engineering (General) > TA164 Bioengineering
T Technology > TA Engineering (General). Civil engineering (General) > TA401-492 Materials of engineering and construction. Mechanics of materials
Q Science > QD Chemistry > QD001-65 General
ID Code:29295
Deposited By:Jamal Seyyed Monfared Zanjani
Deposited On:18 Apr 2016 14:37
Last Modified:09 Nov 2016 10:56

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