Cytotoxic effect of extract from Dunaliella salina against SH-SY5Y neuroblastoma cells
Atasever Arslan, Belkıs and Yılancıoğlu, Kaan and Bekaroğlu, Maide G. and Taşkın, Emre and Altınöz, Eyup and Çetiner, Selim (2015) Cytotoxic effect of extract from Dunaliella salina against SH-SY5Y neuroblastoma cells. General Physiology and Biophysics, 34 (2). pp. 201-207. ISSN 0231-5882 (Print) 1338-4325 (Online)
Official URL: http://www.ncbi.nlm.nih.gov/pubmed/25675388
Cytotoxic effects of essential oils extracted from Dunaliella sauna on SH-SY5Y human neuroblastoma cells were investigated in this study. GC-MS analysis was used for determination of the composition of essential oils found in Dunaliella salina extract. All experimented concentrations of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells were significantly more cytotoxic than the tested concentrations of the extract on ECV304 human endothelial cells used as a control. Fifthy compounds were detected in GC-MS analysis of the extract, and five major compounds were predominantly found as follows: octadecanoic acid, methyl ester (27.43%); hexadecanoic acid, methyl ester (Cas) methyl palmitate (24.82%); 9,12,15-octadecatrienoic acid, ethyl ester, (Z,Z,Z)- (7.39%); octadecanoic acid (5.03%), pentadecanoic acid (3.60%). The cytotoxic activity of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells might be due to high concentrations of octadecanoic acid and hexadecanoic acid. Furthermore, results indicate that the extract demonstrates some proliferative effect on ECV304 cells in a dose-dependent manner between 0.25 and 5 mu g/ml. These results suggest that Dunaliella sauna may have anticancer potential against human neuroblastoma cells.
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