title   
  

Cytotoxic effect of extract from Dunaliella salina against SH-SY5Y neuroblastoma cells

Atasever Arslan, Belkıs and Yılancıoğlu, Kaan and Bekaroğlu, Maide G. and Taşkın, Emre and Altınöz, Eyup and Çetiner, Selim (2015) Cytotoxic effect of extract from Dunaliella salina against SH-SY5Y neuroblastoma cells. General Physiology and Biophysics, 34 (2). pp. 201-207. ISSN 0231-5882 (Print) 1338-4325 (Online)

[img]PDF - Repository staff only - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
431Kb

Official URL: http://www.ncbi.nlm.nih.gov/pubmed/25675388

Abstract

Cytotoxic effects of essential oils extracted from Dunaliella sauna on SH-SY5Y human neuroblastoma cells were investigated in this study. GC-MS analysis was used for determination of the composition of essential oils found in Dunaliella salina extract. All experimented concentrations of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells were significantly more cytotoxic than the tested concentrations of the extract on ECV304 human endothelial cells used as a control. Fifthy compounds were detected in GC-MS analysis of the extract, and five major compounds were predominantly found as follows: octadecanoic acid, methyl ester (27.43%); hexadecanoic acid, methyl ester (Cas) methyl palmitate (24.82%); 9,12,15-octadecatrienoic acid, ethyl ester, (Z,Z,Z)- (7.39%); octadecanoic acid (5.03%), pentadecanoic acid (3.60%). The cytotoxic activity of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells might be due to high concentrations of octadecanoic acid and hexadecanoic acid. Furthermore, results indicate that the extract demonstrates some proliferative effect on ECV304 cells in a dose-dependent manner between 0.25 and 5 mu g/ml. These results suggest that Dunaliella sauna may have anticancer potential against human neuroblastoma cells.

Item Type:Article
Uncontrolled Keywords:Algae; Cytotoxicity; Dunaliella salina; Essential oil; SH-SY5Y human neuroblastoma cells
Subjects:R Medicine > RS Pharmacy and materia medica
ID Code:28521
Deposited By:Selim Çetiner
Deposited On:23 Dec 2015 15:39
Last Modified:23 Dec 2015 16:02

Repository Staff Only: item control page