title   
  

MicroRNA nomenclature and the need for a revised naming prescription

Budak, Hikmet and Bulut, Reyyan Fatima and Kantar, Melda and Alptekin, Burcu (2015) MicroRNA nomenclature and the need for a revised naming prescription. Briefings in Functional Genomics (Sl) . ISSN 2041-2649 (Print) 2041-2657 (Online)

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Official URL: http://dx.doi.org/10.1093/bfgp/elv026

Abstract

A central environment and interface for microRNA (miRNA) registry and repository and a general standardized framework for their systematic annotation was established over a decade ago. However, the numbers of experimentally and computationally identified miRNAs are swiftly accumulating, and new aspects of miRNA-mediated gene regulation are being revealed. Currently, it is of great significance that the annotation framework should be redefined to include newly discovered miRNA species such as the variants of mature miRNAs (isomiRNAs), and organellar miRNAs: cipomiRNAs and mitomiRNAs. It is also of great importance that key terminology referring to the novelty, evolutionary history or biogenesis of miRNAs, as well as the confidence of their identification are standardized in the literature and disseminated in a central miRNA registry. Here, we review the status of miRNA nomenclature, curation and critical points of need for a revision of miRNA nomenclature and terminology.

Item Type:Article
Uncontrolled Keywords:microRNAs; isomiRNAs; mitomiRs; cipomiRs; bona fide miRNAs; canonical miRNAs
Subjects:Q Science > Q Science (General)
ID Code:27971
Deposited By:Hikmet Budak
Deposited On:18 Dec 2015 22:35
Last Modified:18 Dec 2015 22:35

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