title   
  

Amino acid preferences at neddylation sites

Yavuz, Ahmet Sinan and Sözer, Namık Berk and Sezerman, Uğur (2014) Amino acid preferences at neddylation sites. In: International Conference on Applied Informatics for Health and Life Sciences (AIHLS 2014), Kuşadası, Turkey

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Abstract

Neddylation is a dynamic post-translational modification in which NEDD8 proteins are covalently attached to the target site lysine residue. Neddylation may affect a target protein’s localization, binding partners and structure. Targets of this modification have commonly found in nucleus and the most well characterized target family is cullins, which is modulating ubiquitination and proteosomal degradation system in a cell. Disruptions in neddylation pathway implicated in various diseases such as Alzheimer’s, Parkinson’s and cancer. Therefore, understanding neddylation site recognition bears a huge importance in understanding the complete functional mechanism of this post-translational modification and revealing the mechanisms of associated diseases towards a cure. However, there is no study in literature investigating whether a common neddylation site motif exists or not. In this work, we have identified various amino acid preferences and hydrophobicity patterns seen in neddylation sites, differing from not neddylated lysine residues.

Item Type:Papers in Conference Proceedings
Subjects:Q Science > Q Science (General)
ID Code:26330
Deposited By:Uğur Sezerman
Deposited On:11 Dec 2014 12:00
Last Modified:11 Dec 2014 12:00

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