Decreased IFN-gamma and IL-12 levels in panic disorder
Tukel, Raşit and Atasever Arslan, Belkıs and Ertekin, Banu Aslantaş and Ertekin, Erhan and Oflaz, Serap and Ergen, Arzu and Kuruca, Serap Erdem and İşbir, Turgay (2012) Decreased IFN-gamma and IL-12 levels in panic disorder. Journal of Psychosomatic Research, 73 (1). pp. 63-67. ISSN 0022-3999
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Official URL: http://dx.doi.org/10.1016/j.jpsychores.2012.04.012
Objective: The aim of this study is to assess the measures of proinflammatory cytokines in patients with panic disorder in comparison with the healthy subjects. Methods: Twenty three patients with panic disorder with or without agoraphobia and twenty three controls were recruited for the study. Plasma samples of all subjects were analyzed for TNF-alpha, IFN-gamma, IL-1 beta, IL-2, IL-6, and IL-12 concentrations and NK-cell activity is measured in the peripheral blood samples of the subjects. Results: We found significant differences on the mean values of IL-12 (p = 0.01) and IFN-gamma (p = 0.02) between the panic disorder and control groups. In a logistic regression analysis, IFN-gamma values were significant statistical predictors of the presence of panic disorder (B = -0.07, SE = 0.03, p = 0.04). Conclusion: The most important implication of our results is to suggest a relation between panic disorder and low levels of IFN-gamma compatible with the results of the animal studies showing that IFN-gamma plays a role by acting to regulate the development of anxiety-like behaviors.
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