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Pathological aspects of lipid peroxidation

Negre-Salvayre, Anne and Auge, Nathalie and Ayala, Victoria and Başağa, Hüveyda and Boada, Jordi and Brenke, Rainer and Chapple, Sarah and Cohen, Guy and Feher, Janos and Grune, Tilman and Lengyel, Gabriella and Mann, Giovanni E. and Pamplona, Reinald and Poli, Giuseppe and Portero-Otin, Manuel and Riahi, Yael and Salvayre, Robert and Sasson, Shlomo and Serrano, Jose and Shamni, Ofer and Siems, Werner and Siow, Richard C. M. and Wiswedel, Ingrid and Zarkovic, Kamelija and Zarkovic, Neven (2010) Pathological aspects of lipid peroxidation. Free Radical Research (Sp. Iss. SI), 44 (10). pp. 1125-1171. ISSN 1071-5762

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Official URL: http://dx.doi.org/10.3109/10715762.2010.498478

Abstract

Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.

Item Type:Article
Additional Information:Document Type: Review
Uncontrolled Keywords:Oxidative stress; oxidative homeostasis; reactive oxygen species; lipid peroxidation; 4-Hydroxynonenal; neurodegenerative diseases; Alzheimer's disease; amyotrophic lateral sclerosis; Parkinson's disease; liver disease; fatty liver; atherosclerosis; redox equilibrium; cell signalling; oxidized phospholipids; oxysterol; diabetes; diabetes complications; 4-hydroxydodecadienal; 4-hydroxynonenal; pre-eclampsia; HELLP syndrome; IUGR; glutathione; redox signaling; Nrf2; antioxidant enzymes; foetal endothelium; renal diseases; lymphoedema; hyperglycaemia; advanced glycation end-products; cancer
Subjects:Q Science > QH Natural history > QH506 Molecular biology
ID Code:14706
Deposited By:Hüveyda Başağa
Deposited On:08 Oct 2010 14:46
Last Modified:25 May 2011 14:06

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