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Nanocrystalline diamond film for biosensor applications

Qureshi, Anjum and Gürbüz, Yaşar and Howell, Mick and Kang, Weng P. and Davidson, Jımmy L. (2010) Nanocrystalline diamond film for biosensor applications. In: 20th European Conference on Diamond, Diamond-Like Materials, Carbon Nanotubes and Nitrides, Athens, Greece

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Official URL: http://dx.doi.org/10.1016/j.diamond.2010.01.012

Abstract

In this study, we have developed a novel capacitive biosensor based oil interdigitated gold nanodiamond (GID-NCD) electrode for detection of C-reactive protein (CRP) antigen. CRP is one of the plasma proteins known as acute-phase proteins and its levels rise dramatically during inflammatory processes occurring in the body. It has been reported that CRP in serum can be used for risk assessment of cardiovascular diseases. The antibodies immobilization were confirmed by Fourier transform spectroscopy (FTIR) and contact angle measurements. In this capacitive biosensor, nanocrystalline diamond acting as a dielectric layer between the electrodes. The CRP antigen detection was performed by capacitive/dielectric-constant measurements. Our results showed that the response of NCD-based capacitive-based biosensor for CRP antigen was dependent on both concentration (25-800 ng/ml) as well as frequency (50-350 MHz). Furthermore, using optimized conditions, the biosensors developed in this study can be potentially used for detection of elevated level of risk markers protein in suspected subjects for early diagnosis of disease.

Item Type:Papers in Conference Proceedings
Uncontrolled Keywords:Nanocrystalline diamond film; Antibody; Capacitive; C-reactive protein; Biosensor
Subjects:T Technology > TA Engineering (General). Civil engineering (General) > TA401-492 Materials of engineering and construction. Mechanics of materials
ID Code:13641
Deposited By:Yaşar Gürbüz
Deposited On:30 Dec 2009 15:29
Last Modified:25 May 2011 14:12

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