Label-free biosensors for the detection and quantification of cardiovascular risk markers
Kallempudi, Sreenivasa Saravan and Gül, Özgür and Başağa, Hüveyda and Sezerman, Uğur and Gürbüz, Yaşar (2008) Label-free biosensors for the detection and quantification of cardiovascular risk markers. Journal of Sensor Letters, 6 . pp. 1-5. ISSN 1546-198X (Print) 1546-1971 (Online)
Official URL: http://www.aspbs.com/sensorlett/
This paper presents a biosensor implementation for the detection of protein molecules using specific antibodies. Affinity sensors allow the detection and quantification of target molecules in complex mixtures by affinity-based interactions. Immobilized antibody molecules are the probes that bind to specific protein molecules (targets) in biological fluids. In this study, inter-digitated electrodes in the form of capacitance on glass slide were designed, fabricated and used to measure the changes in the dielectric properties of the inter-digitated capacitances. Our results in this study present that with a careful design of micro-interdigitated capacitors, a wider dynamic range and higher sensitivity can be achieved for the detection and quantification of C-Reeactive Protein.
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